Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins
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چکیده
منابع مشابه
Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins
In myocytes, small heat shock proteins (sHSPs) are preferentially translocated under stress to the sarcomeres. The functional implications of this translocation are poorly understood. We show here that HSP27 and αB-crystallin associated with immunoglobulin-like (Ig) domain-containing regions, but not the disordered PEVK domain (titin region rich in proline, glutamate, valine, and lysine), of th...
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Many factors leading to unfolding and misfolding of proteins eventually result in protein aggregation. Stress imposed by high temperature was one of the first aggregation-inducing factors studied, and remains one of the main models in this field. The cell needs chaperone proteins to control and counteract the aggregation process. Elimination of aggregates can be achieved by solubilization of ag...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2014
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.201306077